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Chuān Liàn Zǐ (Jīn Líng Zǐ) 川楝子

Pharmaceutical name Toosendan Fructus toosendan fruit, sichuan chinaberry/pagoda tree
Category Regulate Qi
Key Properties Cools Heat
Regulates the Qi
Stops Pain
Properties Bitter
Slightly Toxic
Tropism UB, LV, SI, ST
Actions & Indications 1) Dredges LV Qi, Relieves Constraint, Stop Pain, Conducts Heat Out from below
2) Kills Parasites & Stops Pain (abdominal pain associated with parasites)
(Shan disorder)
Dosages 4.5-9g
Contraindications (TCM) Cold from Deficiency of SP & ST
Contraindications (Western)
Chemical Composition Toosendanin, mergsine, melianone, melianol, melianediol, melialactone, azadirachtin, 21-o-acetyltoosendatriol, lipomelianol
Pharmacological Effects • Antiparasitic: demonstrated marked effectiveness against intestinal parasites; has been proposed that toosendanin causes constant muscle contraction in the parasites, leading to muscle fatigue, inability to adhere to intestines, and eventual expulsion of parasites; expulsion of parasites generally occurs 24 to 48 hours after administration; when compared to santonin, herb has slower onset but more prolonged duration of effect
• Respiratory: administration in rats via intravenous or intramuscular injection leads to dyspnea, a reaction attributed to its inhibiting influence on CNS; dyspnea may be reversed with administration of nicotine
• Antitoxin: survival rate over 80% in rats when toosendanin is administered within 6 hours of exposure to botulism, and approximately 50% in monkeys when administered within 24 hours
Herb-Drug Interactions
Classical Formula(s)

Tian Tai Wu Yao San (Top-Quality Lindera Powder) 天臺烏藥散 (天台烏药散)

Zhen Gan Xi Feng Tang (Sedate the Liver and Extinquish Wind Decoction) 鎮肝熄風湯

Jin Ling Zi San (Melia Toosendan Powder) 金鈴子散

Yi Guan Jian (Linking decoction) 一貫煎


This information is a reference tool for Chinese herbal studies. It is not intended to replace professional medical advice. Please consult a primary health professional if you require health advisory.